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Review
. 2005 Oct 7;123(1):13-24.
doi: 10.1016/j.cell.2005.09.019.

Right place, right time, and only once: replication initiation in metazoans

Yuichi J Machida  1 , Joyce L Hamlin, Anindya Dutta
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Free article
Review

Right place, right time, and only once: replication initiation in metazoans

Yuichi J Machida et al. Cell. .
Free article

Abstract

DNA replication is tightly regulated at the initiation step by both the cell cycle machinery and checkpoint pathways. Here, we discuss recent advances in understanding how replication is initiated in metazoans at the correct chromosome positions, at the appropriate time, and only once per cell cycle.

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