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. 2005 Nov 25;337(3):901-7.
doi: 10.1016/j.bbrc.2005.09.132. Epub 2005 Sep 30.

Epigenetic regulation of mammalian pericentric heterochromatin in vivo by HP1

Niki Kourmouli  1 , Yuh-man Sun, Sjaak van der Sar, Prim B Singh, Jeremy P Brown
Affiliations

Epigenetic regulation of mammalian pericentric heterochromatin in vivo by HP1

Niki Kourmouli et al. Biochem Biophys Res Commun. .

Abstract

We developed a model system whereby HP1 can be targeted to pericentric heterochromatin in ES cells lacking Suv(3)9h1/2 histone methyltransferase (HMTase) activities. HP1 so targeted can reconstitute tri-methylated lysine 9 of histone H3 (Me(3)K9H3) and tri-methylated lysine 20 of histone H4 (Me(3)K20H4) at pericentric heterochromatin, indicating that HP1 can regulate the distribution of these histone modifications in vivo. Both homo- and hetero-typic interactions between the HP1 isotypes were demonstrated in vivo as were HP1 interactions with the ESET/SETDB1 HMTase and the ATRX chromatin remodelling enzyme. We conclude that HP1 not only "deciphers" the histone code but can also "encode it".

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