This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features!

Skip to main page content

Add to Collections

Your saved search

Name of saved search:

Search terms:

Test search terms

Would you like email updates of new search results?

Yes
No

Email: (change)

Frequency:

Which day?

Which day?

Report format:

Send at most:

Send even when there aren't any new results

Optional text in email:

Your RSS Feed

. 2006 Jan;82(1):3-4.

doi: 10.1016/j.exer.2005.08.012. Epub 2005 Oct 5.

Focus on molecules: lumican

Winston W-Y Kao¹, James L Funderburgh, Ying Xia, Chia-Yang Liu, Gary W Conrad

Affiliations

PMID: 16213485
PMCID: PMC2876311
DOI: 10.1016/j.exer.2005.08.012

Focus on molecules: lumican

Winston W-Y Kao et al. Exp Eye Res. 2006 Jan.

. 2006 Jan;82(1):3-4.

doi: 10.1016/j.exer.2005.08.012. Epub 2005 Oct 5.

Authors

Winston W-Y Kao¹, James L Funderburgh, Ying Xia, Chia-Yang Liu, Gary W Conrad

Affiliation

¹ Department of Ophthalmology, University of Cincinnati, Cincinnati, OH, USA. winston.kao@uc.edu

PMID: 16213485
PMCID: PMC2876311
DOI: 10.1016/j.exer.2005.08.012

No abstract available

PubMed Disclaimer

Figures

Fig. 1 — Fig. 1
Molecular model of lumican 3D structure and lumican functions mediated via cell surface receptor Lumican 3D model was created using Deep View software (http://swissmodel.expasy.org/spdbv) based on homology with decorin crystal structure. Model shows bovine lumican from Cys41 to C-terminus. Cys residues are yellow. Beta-sheet structures are red. Asn proposed to be modified with N-linked oligosaccharides (J. Biol. Chem. 272:28089) are green. Top view imposes hybrid-type N-linked oligosaccharide at modified Asn moieties. Lumican binds to its receptor and transduces signals leading to expression of genes involved in cell proliferation, migration, differentiation and epithelium-mesenchyme transition (EMT).

See this image and copyright information in PMC

Similar articles

Lumican is required for neutrophil extravasation following corneal injury and wound healing.
Hayashi Y, Call MK, Chikama T, Liu H, Carlson EC, Sun Y, Pearlman E, Funderburgh JL, Babcock G, Liu CY, Ohashi Y, Kao WW. Hayashi Y, et al. J Cell Sci. 2010 Sep 1;123(Pt 17):2987-95. doi: 10.1242/jcs.068221. Epub 2010 Aug 10. J Cell Sci. 2010. PMID: 20699360 Free PMC article.
Structure and biological functions of keratan sulfate proteoglycans.
Greiling H. Greiling H. EXS. 1994;70:101-22. doi: 10.1007/978-3-0348-7545-5_7. EXS. 1994. PMID: 8298243 Review.
Modulation of keratan sulfate synthesis on lumican by the action of cytokines on human articular chondrocytes.
Melching LI, Roughley PJ. Melching LI, et al. Matrix Biol. 1999 Aug;18(4):381-90. doi: 10.1016/s0945-053x(99)00033-5. Matrix Biol. 1999. PMID: 10517185
Epithelial repair: roles of extracellular matrix.
Saika S, Ohnishi Y, Ooshima A, Liu CY, Kao WW. Saika S, et al. Cornea. 2002 Mar;21(2 Suppl 1):S23-9. doi: 10.1097/00003226-200203001-00006. Cornea. 2002. PMID: 11995806 Review.
Lumican promotes corneal epithelial wound healing.
Liu CY, Kao WW. Liu CY, et al. Methods Mol Biol. 2012;836:285-90. doi: 10.1007/978-1-61779-498-8_18. Methods Mol Biol. 2012. PMID: 22252641

See all similar articles

Cited by

Lumican is required for neutrophil extravasation following corneal injury and wound healing.
Hayashi Y, Call MK, Chikama T, Liu H, Carlson EC, Sun Y, Pearlman E, Funderburgh JL, Babcock G, Liu CY, Ohashi Y, Kao WW. Hayashi Y, et al. J Cell Sci. 2010 Sep 1;123(Pt 17):2987-95. doi: 10.1242/jcs.068221. Epub 2010 Aug 10. J Cell Sci. 2010. PMID: 20699360 Free PMC article.
Human primary corneal fibroblasts synthesize and deposit proteoglycans in long-term 3-D cultures.
Ren R, Hutcheon AE, Guo XQ, Saeidi N, Melotti SA, Ruberti JW, Zieske JD, Trinkaus-Randall V. Ren R, et al. Dev Dyn. 2008 Oct;237(10):2705-15. doi: 10.1002/dvdy.21606. Dev Dyn. 2008. PMID: 18624285 Free PMC article.
Extracellular Matrix Deposition and Remodeling after Corneal Alkali Burn in Mice.
Mutoji KN, Sun M, Elliott G, Moreno IY, Hughes C, Gesteira TF, Coulson-Thomas VJ. Mutoji KN, et al. Int J Mol Sci. 2021 May 27;22(11):5708. doi: 10.3390/ijms22115708. Int J Mol Sci. 2021. PMID: 34071909 Free PMC article.
Lumican Peptides: Rational Design Targeting ALK5/TGFBRI.
Gesteira TF, Coulson-Thomas VJ, Yuan Y, Zhang J, Nader HB, Kao WW. Gesteira TF, et al. Sci Rep. 2017 Feb 9;7:42057. doi: 10.1038/srep42057. Sci Rep. 2017. PMID: 28181591 Free PMC article.
Communications via the Small Leucine-rich Proteoglycans: Molecular Specificity in Inflammation and Autoimmune Diseases.
Zeng-Brouwers J, Pandey S, Trebicka J, Wygrecka M, Schaefer L. Zeng-Brouwers J, et al. J Histochem Cytochem. 2020 Dec;68(12):887-906. doi: 10.1369/0022155420930303. Epub 2020 Jul 6. J Histochem Cytochem. 2020. PMID: 32623933 Free PMC article. Review.

See all "Cited by" articles

References

1. Carlson EC, Liu CY, Chikama T, Hayashi Y, Kao CW, Birk DE, Funderburgh JL, Jester JV, Kao WW. Keratocan, a cornea-specific keratan sulfate proteoglycan, is regulated by lumican. J Biol Chem. 2005;280:25541–25547. - PMC - PubMed
1. Chakravarti S, Petroll WM, Hassell JR, Jester JV, Lass JH, Paul J, Birk DE. Corneal opacity in lumican-null mice: defects in collagen fibril structure and packing in the posterior stroma. Invest Ophthalmol Vis Sci. 2000;41:3365–3373. - PMC - PubMed
1. Funderburgh JL, Mitschler RR, Funderburgh ML, Roth MR, Chapes SK, Conrad GW. Macrophage receptors for lumican. A corneal keratan sulfate proteoglycan. Invest Ophthalmol Vis Sci. 1997;38:1159–1167. - PubMed
1. Kao WW, Liu CY. Roles of lumican and keratocan on corneal transparency. Glycoconj J. 2002;19:275–285. - PubMed

Publication types

Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions
Actions
Actions
Actions

Grants and funding

LinkOut - more resources

Full Text Sources
Other Literature Sources
- The Lens - Patent Citations Database
Miscellaneous
- NCI CPTAC Assay Portal