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. 2006 Jan;82(1):3-4.
doi: 10.1016/j.exer.2005.08.012. Epub 2005 Oct 5.

Focus on molecules: lumican

Winston W-Y Kao  1 , James L Funderburgh, Ying Xia, Chia-Yang Liu, Gary W Conrad
Affiliations

Focus on molecules: lumican

Winston W-Y Kao et al. Exp Eye Res. 2006 Jan.
No abstract available

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Figures

Fig. 1
Fig. 1
Molecular model of lumican 3D structure and lumican functions mediated via cell surface receptor Lumican 3D model was created using Deep View software (http://swissmodel.expasy.org/spdbv) based on homology with decorin crystal structure. Model shows bovine lumican from Cys41 to C-terminus. Cys residues are yellow. Beta-sheet structures are red. Asn proposed to be modified with N-linked oligosaccharides (J. Biol. Chem. 272:28089) are green. Top view imposes hybrid-type N-linked oligosaccharide at modified Asn moieties. Lumican binds to its receptor and transduces signals leading to expression of genes involved in cell proliferation, migration, differentiation and epithelium-mesenchyme transition (EMT).
See this image and copyright information in PMC

References

    1. Carlson EC, Liu CY, Chikama T, Hayashi Y, Kao CW, Birk DE, Funderburgh JL, Jester JV, Kao WW. Keratocan, a cornea-specific keratan sulfate proteoglycan, is regulated by lumican. J Biol Chem. 2005;280:25541–25547. - PMC - PubMed
    1. Chakravarti S, Petroll WM, Hassell JR, Jester JV, Lass JH, Paul J, Birk DE. Corneal opacity in lumican-null mice: defects in collagen fibril structure and packing in the posterior stroma. Invest Ophthalmol Vis Sci. 2000;41:3365–3373. - PMC - PubMed
    1. Funderburgh JL, Mitschler RR, Funderburgh ML, Roth MR, Chapes SK, Conrad GW. Macrophage receptors for lumican. A corneal keratan sulfate proteoglycan. Invest Ophthalmol Vis Sci. 1997;38:1159–1167. - PubMed
    1. Kao WW, Liu CY. Roles of lumican and keratocan on corneal transparency. Glycoconj J. 2002;19:275–285. - PubMed

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