Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2006 Feb 15;14(4):1029-38.
doi: 10.1016/j.bmc.2005.09.020. Epub 2005 Oct 5.

Synthesis and properties of 2'-O,4'-C-methyleneoxymethylene bridged nucleic acid

Yoshiyuki Hari  1 , Satoshi Obika, Ryo Ohnishi, Ken Eguchi, Tomohisa Osaki, Hirofumi Ohishi, Takeshi Imanishi
Affiliations

Synthesis and properties of 2'-O,4'-C-methyleneoxymethylene bridged nucleic acid

Yoshiyuki Hari et al. Bioorg Med Chem. .

Abstract

A novel bridged nucleic acid (BNA) analogue, 2'-O,4'-C-methyleneoxymethylene bridged nucleic acid (2',4'-BNA(COC)), was synthesized and incorporated into oligonucleotides. The 2',4'-BNA(COC) modified oligonucleotides showed high binding affinity with an RNA complement and significant enzymatic stability against snake venom phosphodiesterase.

PubMed Disclaimer

Publication types

LinkOut - more resources