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Review
. 2006 Jan 1;97(1):18-32.
doi: 10.1002/jcb.20634.

Apoptosis evasion: the role of survival pathways in prostate cancer progression and therapeutic resistance

Shaun McKenzie  1 , Natasha Kyprianou
Affiliations
Review

Apoptosis evasion: the role of survival pathways in prostate cancer progression and therapeutic resistance

Shaun McKenzie et al. J Cell Biochem. .

Abstract

The ability of a tumor cell population to grow exponentially represents an imbalance between cellular proliferation and cellular attrition. There is an overwhelming body of evidence suggesting the ability of tumor cells to avoid programmed cellular attrition, or apoptosis, is a major molecular force driving the progression of human tumors. Apoptotic evasion represents one of the true hallmarks of cancer and appears to be a vital component in the immunogenic, chemotherapeutic, and radiotherapeutic resistance that characterizes the most aggressive of human cancers [Hanahan and Weinberg, 2000]. The challenges in the development of effective treatment modalities for advanced prostate cancer represent a classic paradigm of the functional significance of anti-apoptotic pathways in the development of therapeutic resistance.

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Figures

Fig. 1
Fig. 1
Signaling cross-talk between survival and apoptosis pathways in prostate cancer cells. [Color figure can be viewed in the online issue, which is available at www.interscience.wiley.com.]
See this image and copyright information in PMC

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