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. 2006 Jun 1;126(2):176-9.
doi: 10.1016/j.ejogrb.2005.08.014. Epub 2005 Oct 10.

The effect of a nicorandil congener on isolated human myometrium

K Parimala  1 , Jacob Peedicayil, Abraham Peedicayil, Nissy Nelson, Kalpana Ernest
Affiliations

The effect of a nicorandil congener on isolated human myometrium

K Parimala et al. Eur J Obstet Gynecol Reprod Biol. .

Abstract

Objective: To determine the effect of a nicorandil congener, SG-209 on the myometrium.

Study design: Isolated strips of myometrium, from nine women who underwent hysterectomy, were made to contract with 55 mM KCl before and after incubation with three concentrations of SG-209 (1.5, 3.0 and 10 microM). The mean height of contraction and the area under the curve were analysed using a non-parametric test.

Results: At a 10 microM concentration, SG-209 significantly decreased the mean area under the curve from 10.8 to 2.5 cm2 (p<0.05).

Conclusion: SG-209 significantly relaxes the human non-pregnant myometrium. Along with its congener, nicorandil, it may be useful in clinical conditions that require uterine relaxation.

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