Comment
doi: 10.1073/pnas.0507120102.
Epub 2005 Oct 10.
The opened processivity clamp slides into view
Affiliations
- PMID: 16217036
- PMCID: PMC1257719
- DOI: 10.1073/pnas.0507120102
Item in Clipboard
Comment
The opened processivity clamp slides into view
Proc Natl Acad Sci U S A.
.
No abstract available
Figures
Architectural similarities in clamp loaders and sliding clamps. (A) Stylized images of the loaders and clamps from bacteria, eukaryotes, bacteriophage T4, and archaea. RFCS, RFC small subunit; RFCL, RFC large subunit. (B) Structure of the opened clamp as suggested by molecular dynamics simulations and an EM-derived structural model. The six-clamp subdomains are arranged as a planar ring in the closed form. Molecular dynamics and an EM-derived model suggest that when the clamp is opened, the subdomains adopt a right-handed spiral or “lock washer” conformation.
Comment on
-
Open clamp structure in the clamp-loading complex visualized by electron microscopic image analysis.Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):13795-800. doi: 10.1073/pnas.0506447102. Epub 2005 Sep 16. Proc Natl Acad Sci U S A. 2005. PMID: 16169902 Free PMC article.
-
Out-of-plane motions in open sliding clamps: molecular dynamics simulations of eukaryotic and archaeal proliferating cell nuclear antigen.Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):13801-6. doi: 10.1073/pnas.0506430102. Epub 2005 Sep 16. Proc Natl Acad Sci U S A. 2005. PMID: 16169903 Free PMC article.
Similar articles
-
Fluorescence measurements on the E.coli DNA polymerase clamp loader: implications for conformational changes during ATP and clamp binding.J Mol Biol. 2004 Mar 5;336(5):1047-59. doi: 10.1016/j.jmb.2003.12.074. J Mol Biol. 2004. PMID: 15037068
-
A sliding clamp monkey wrench.Nat Struct Biol. 2001 Oct;8(10):829-31. doi: 10.1038/nsb1001-829. Nat Struct Biol. 2001. PMID: 11573082 No abstract available.
-
Inhibition of protein interactions with the beta 2 sliding clamp of Escherichia coli DNA polymerase III by peptides from beta 2-binding proteins.Biochemistry. 2004 May 18;43(19):5661-71. doi: 10.1021/bi036229j. Biochemistry. 2004. PMID: 15134440
-
Clamp loaders and replication initiation.Curr Opin Struct Biol. 2006 Feb;16(1):35-41. doi: 10.1016/j.sbi.2005.12.004. Epub 2006 Jan 11. Curr Opin Struct Biol. 2006. PMID: 16377178 Review.
-
Thirty years of Escherichia coli DNA gyrase: from in vivo function to single-molecule mechanism.Biochimie. 2007 Apr;89(4):490-9. doi: 10.1016/j.biochi.2007.02.012. Epub 2007 Feb 24. Biochimie. 2007. PMID: 17397985 Review.
References
-
- Johnson, A. & O'Donnell, M. (2005) Annu. Rev. Biochem. 74, 283–315. - PubMed
-
- Grabowski, B. & Kelman, Z. (2003) Annu. Rev. Microbiol. 57, 487–516. - PubMed
-
- Stukenberg, P. T., Studwell-Vaughan, P. S. & O'Donnell, M. (1991) J. Biol. Chem. 266, 11328–11334. - PubMed
-
- Kong, X.-P., Onrust, R., O'Donnell, M. & Kuriyan, J. (1992) Cell 69, 425–437. - PubMed
-
- O'Donnell, M., Jeruzalmi, D. & Kuriyan, J. (2001) Curr. Biol. 11, R935–R946. - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
