Central pontine myelinolysis: case series and review

Abstract

Objective: To review central pontine myelinolysis (CPM) and osmotic demyelination syndrome (ODS) and describe the clinical features, etiologic factors, and clinical outcomes of 6 patients diagnosed with CPM or ODS.

Study design: A retrospective case series.

Methods: Medical records of patients diagnosed with CPM or ODS at Marshfield Clinic/St. Joseph's Hospital from 1986 to 2003 were reviewed. Chart abstraction was completed with a standardized data abstraction form.

Results: Six patients were identified, ranging in age from 31-73 years (mean age = 51.5 years). Clinical presentations were nonspecific. Common symptoms included lethargy and dysarthria. Five of the 6 patients had chronic alcoholism. All had improvements in their clinical conditions upon hospital discharge.

Conclusions: CPM and ODS are rare demyelinating diseases of the pons and extrapontine sites. Prompt diagnosis and management of associated complications are essential for favorable clinical outcomes.