doi: 10.1039/b509757f.
Epub 2005 Sep 15.
Total synthesis of a diastereomer of the marine natural product clavosolide A
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- PMID: 16220183
- DOI: 10.1039/b509757f
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Total synthesis of a diastereomer of the marine natural product clavosolide A
Chem Commun (Camb).
.
Abstract
The first total synthesis of the reported structure of the sponge metabolite clavosolide A is described using a Prins cyclisation to assemble the tetrahydropyran core followed by manipulation of the side-chain, dimerisation and finally glycosidation.
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