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. 2005 Oct 28:(40):5097-9.
doi: 10.1039/b509757f. Epub 2005 Sep 15.

Total synthesis of a diastereomer of the marine natural product clavosolide A

Conor S Barry  1 , Nick Bushby, Jonathan P H Charmant, Jon D Elsworth, John R Harding, Christine L Willis
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Total synthesis of a diastereomer of the marine natural product clavosolide A

Conor S Barry et al. Chem Commun (Camb). .

Abstract

The first total synthesis of the reported structure of the sponge metabolite clavosolide A is described using a Prins cyclisation to assemble the tetrahydropyran core followed by manipulation of the side-chain, dimerisation and finally glycosidation.

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