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. 1992 Mar;36(3):690-2.
doi: 10.1128/AAC.36.3.690.

Use of high-dose fluconazole as salvage therapy for cryptococcal meningitis in patients with AIDS

A J Berry  1 , M G Rinaldi, J R Graybill
Affiliations

Use of high-dose fluconazole as salvage therapy for cryptococcal meningitis in patients with AIDS

A J Berry et al. Antimicrob Agents Chemother. 1992 Mar.

Abstract

Eight patients with AIDS were treated orally with 800 mg of fluconazole daily for cryptococcal meningitis for a mean duration of 4.5 months. Previous antifungal treatment had failed for all of the patients. No major toxicity was observed. Three patients died from cryptococcal infection. High-dose fluconazole may be effective salvage therapy for cryptococcal meningitis.

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