Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2005 Sep;13(9):1566-71.
doi: 10.1038/oby.2005.192.

Adiponectin levels during low- and high-fat eucaloric diets in lean and obese women

Evan S Berk  1 , Albert J Kovera, Carol N Boozer, F X Pi-Sunyer, Julia A Johnson, Jeanine B Albu
Affiliations

Adiponectin levels during low- and high-fat eucaloric diets in lean and obese women

Evan S Berk et al. Obes Res. 2005 Sep.

Abstract

Objective: Adiponectin influences insulin sensitivity (S(I)) and fat oxidation. Little is known about changes in adiponectin with changes in the fat content of eucaloric diets. We hypothesized that dietary fat content may influence adiponectin according to an individual's SI.

Research methods and procedures: We measured changes in adiponectin, insulin, glucose, and leptin in response to high-fat (HF) and low-fat (LF) eucaloric diets in lean (n = 10) and obese (n = 11) subjects. Obese subjects were further subdivided in relation to a priori SI.

Results: We found significantly higher insulin, glucose, and leptin and lower adiponectin in obese vs. lean subjects during both HF and LF. The mean group values of these measurements, including adiponectin (lean, HF 21.9 +/- 9.8; LF, 20.8 +/- 6.6; obese, HF 10.0 +/- 3.3; LF, 9.5 +/- 2.3 ng/mL; mean +/- SD), did not significantly change between HF and LF diets. However, within the obese group, the insulin-sensitive subjects had significantly higher adiponectin during HF than did the insulin-resistant subjects. Additionally, the change in adiponectin from LF to HF diet correlated positively with the obese subjects' baseline SI.

Discussion: Although in lean and obese women, group mean values for adiponectin did not change significantly with a change in fat content of a eucaloric diet, a priori measured SI in obese subjects predicted an increase in adiponectin during the HF diet; this may be a mechanism that preserves SI in an already obese group.

PubMed Disclaimer

Figures

Figure 1
Figure 1
The change in adiponectin (nanograms per milliliter) levels between HF and LF diets correlated with subjects’ baseline SI in obese women (r = 0.78, p = 0.005). (Black circles) IS, SI < 2.5. (White circles) IR, SI > 2.5.
See this image and copyright information in PMC

References

    1. Mokdad AH, Bowman BA, Ford ES, Vinicor F, Marks JS, Kaplan JP. The continuing epidemic of obesity and diabetes in the United States. JAMA. 2001;286:1195–200. - PubMed
    1. Maeda K, Okubo K, Shimomuta I, Funahashi T, Matsuzava Y, Matsubuza K. cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (Adipose most abundant gene transcript 1) Biochem Biophys Res Comm. 1996;221:286–9. - PubMed
    1. Diez J, Iglesias M. The role of the novel adipocyte-derived hormone adiponectin in human disease. Eur J Endo. 2003;148:293–300. - PubMed
    1. Yamauachi T, Koman J, Waki H, et al. The fat derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med. 2001;7:941–6. - PubMed
    1. Arita Y, Kihora S, Ouchi N, et al. Paradoxical decrease of adipose specific protein, adiponectin in obesity. Biochem Biophys Res Commun. 1999;257:79–83. - PubMed

Publication types