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Review
. 2005 Sep 21;11(35):5423-32.
doi: 10.3748/wjg.v11.i35.5423.

Treatment of Zollinger-Ellison syndrome

Paola Tomassetti  1 , Davide Campana, Lydia Piscitelli, Elena Mazzotta, Emilio Brocchi, Raffaele Pezzilli, Roberto Corinaldesi
Affiliations
Review

Treatment of Zollinger-Ellison syndrome

Paola Tomassetti et al. World J Gastroenterol. .

Abstract

In this article, we have reviewed the main therapeutic measures for the treatment of Zollinger-Ellison syndrome (ZES). Review of the literature was based on computer searches (Pub-Med, Index Medicus) and personal experiences. We have evaluated all the measures now available for treating patients with sporadic gastrinomas or gastrinomas associated with Multiple Endocrine Neoplasia Type 1, (MEN 1) including medical therapy such as antisecretory drugs and somatostatin analogs (SST), chemotherapy and chemoembolization, and surgical procedures. In ZES patients, the best therapeutic procedure is surgery which, if radical, can be curative. Medical treatment can be the best palliative therapy and should be used, when possible, in association with surgery, in a multimodal therapeutic approach.

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Figures

Figure 1
Figure 1
Diagnostic algorithm for Zollinger-Ellison Syndrome. SRS: somatostatin receptor scintigraphy; CT: computed tomography; MRI: magnetic resonance imaging; US: ultrasonography; EUS: endoscopic ultrasonography.
Figure 2
Figure 2
Therapeutic algorithm of Zollinger-Ellison Syndrome. PPI: proton pump inhibitors; SST: somatostatin analogs; IFN: interferon.
See this image and copyright information in PMC

References

    1. Zollinger RM, Ellison EH. Primary peptic ulcerations of the jejunum associated with islet cell tumors of the pancreas. 1955. CA Cancer J Clin. 1989;39:231–247. - PubMed
    1. Jensen RT, Gardner JD, Raufman JP, Pandol SJ, Doppman JL, Collen MJ. Zollinger-Ellison syndrome: current concepts and management. Ann Intern Med. 1983;98:59–75. - PubMed
    1. Jensen RT, Doppman JL, Gardner JD. Gastrinoma. In: Go V, editor. LW, Brooks FA, DiMagno EP, Gardner JD, Lebenthal E, Scheele GA, eds. The exlocrine pancreas: biology, pathobiology and disease. New York: Raven Press; 1986. pp. 727–744.
    1. Norton JA, Jensen RT. Current surgical management of Zollinger-Ellison syndrome (ZES) in patients without multiple endocrine neoplasia-type 1 (MEN1) Surg Oncol. 2003;12:145–151. - PubMed
    1. Pipeleers-Marichal M, Somers G, Willems G, Foulis A, Imrie C, Bishop AE, Polak JM, Häcki WH, Stamm B, Heitz PU. Gastrinomas in the duodenums of patients with multiple endocrine neoplasia type 1 and the Zollinger-Ellison syndrome. N Engl J Med. 1990;322:723–727. - PubMed

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