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. 2005 Sep 21;11(35):5565-7.
doi: 10.3748/wjg.v11.i35.5565.

Detection of HBsAg, HBcAg, and HBV DNA in ovarian tissues from patients with HBV infection

Li-Zhang Chen  1 , Xue-Gong Fan, Jian-Ming Gao
Affiliations

Detection of HBsAg, HBcAg, and HBV DNA in ovarian tissues from patients with HBV infection

Li-Zhang Chen et al. World J Gastroenterol. .

Abstract

Aim: To investigate the presence of HBsAg, HBcAg, and HBV DNA in ovarian tissues from patients with HBV infection.

Methods: HBsAg and HBcAg were examined in ovarian biopsy tissues from 26 patients with HBV infection by immunocytochemistry, and HBV DNA was detected in ovarian tissues by PCR.

Results: HBsAg and HBcAg were present with the same positive rate of 34.6% (9/26). The total positive rate was 46.2% (12/26). HBsAg and HBcAg were positive in 6 (23.1%) of the 26 patients. Brown positive particles were diffusely distributed in ovarian cells. The positive rate of HBV DNA was 58.3% (7/12).

Conclusion: HBsAg, HBcAg, and HBV DNA can be detected in ovarian tissues from patients with HBV infection. The presence of HBsAg and HBcAg in ovarian tissues does not correlate with the HBV markers in serum.

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Figures

Figure 1
Figure 1
Positive HBsAg (A) expression and positive HBcAg (B) expression in ovarian tissue and negative control (C and D).
Figure 2
Figure 2
Detection of HBV DNA in ovarian tissue by PCR. M: DNA marker; lanes 1, 3, 4 and 5: positive samples; lane 6: negative control; lane 7: positive control.
See this image and copyright information in PMC

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