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Review
. 2004 Dec;31(6):419-40.
doi: 10.1007/s10928-005-5910-2.

Modelling and simulation in the development and use of anti-cancer agents: an underused tool?

Ferdinand Rombout  1 , Leon Aarons, Mats Karlsson, Anthony Man, France Mentré, Peter Nygren, Amy Racine, Hans Schaefer, Jean-Louis Steimer, Iñaki Troconiz, Achiel van Peer; COST B15 Experts
Affiliations
Review

Modelling and simulation in the development and use of anti-cancer agents: an underused tool?

Ferdinand Rombout et al. J Pharmacokinet Pharmacodyn. 2004 Dec.

Abstract

To help identify the role of modelling and simulation in the development of anti-cancer agents, their main advantages and the obstacles to their rational use, an expert meeting was organized by COST B15. This manuscript presents a synthesis of views expressed at that meeting and indicates future directions. The manuscript also shows some examples where modelling and simulation have proven to be of relevant value in the drug development process for anti-cancer agents.

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