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. 2005 Oct;13(10):914-7.
doi: 10.1176/appi.ajgp.13.10.914.

Selective reductions in plasma Abeta 1-42 in healthy elderly subjects during longitudinal follow-up: a preliminary report

Nunzio Pomara  1 , Lisa M Willoughby, John J Sidtis, Pankaj D Mehta
Affiliations

Selective reductions in plasma Abeta 1-42 in healthy elderly subjects during longitudinal follow-up: a preliminary report

Nunzio Pomara et al. Am J Geriatr Psychiatry. 2005 Oct.

Abstract

Objective: Longitudinal changes in plasma beta amyloid protein 1-42 and 1-40 (Abeta42 and Abeta40) levels and possible relationships with cognitive decline and apolipoprotein (APOE) genotype were studied in healthy elderly individuals.

Methods: Authors determined cognitive level and plasma Abeta40 and Abeta42 levels twice, approximately 4 years apart, in 34 elderly subjects.

Results: Analyses revealed a selective reduction in Abeta42 levels at follow-up, which were not modulated by the epsilon4 allele. Greater reductions and higher baseline plasma Abeta42 levels were associated with reductions in cognitive scores.

Conclusions: Alterations in plasma Abeta42 levels may be associated with subtle cognitive decline in elderly subjects without dementia.

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