Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2005 Oct 14;310(5746):306-10.
doi: 10.1126/science.1118947.

Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3

Tai-Lung Cha  1 , Binhua P Zhou, Weiya Xia, Yadi Wu, Cheng-Chieh Yang, Chun-Te Chen, Bo Ping, Arie P Otte, Mien-Chie Hung
Affiliations

Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3

Tai-Lung Cha et al. Science. .

Abstract

Enhancer of Zeste homolog 2 (EZH2) is a methyltransferase that plays an important role in many biological processes through its ability to trimethylate lysine 27 in histone H3. Here, we show that Akt phosphorylates EZH2 at serine 21 and suppresses its methyltransferase activity by impeding EZH2 binding to histone H3, which results in a decrease of lysine 27 trimethylation and derepression of silenced genes. Our results imply that Akt regulates the methylation activity, through phosphorylation of EZH2, which may contribute to oncogenesis.

PubMed Disclaimer

Publication types

MeSH terms

Substances