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Review
. 2005 Nov;17(6):617-21.
doi: 10.1097/01.cco.0000181405.60213.1c.

Cellular adoptive immunotherapy after allogeneic stem cell transplantation

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Review

Cellular adoptive immunotherapy after allogeneic stem cell transplantation

Anton V M B Schattenberg et al. Curr Opin Oncol. 2005 Nov.

Abstract

Purpose of review: This review presents the role of donor lymphocyte infusion, natural killer cells, and dendritic cells in cellular immunotherapy after allogeneic stem cell transplantation.

Recent findings: It becomes increasingly possible to infuse more specialized subsets of lymphocyte cells after transplantation. The infusion of natural killer cells, especially in non human leukocyte antigen-identical transplantation, may become an important tool in enhancing the graft-versus-tumor effect. Vaccination of patients after stem cell transplantation with autologous-derived dendritic cells merits further investigation.

Summary: Stem cell transplantation has evolved to a specialized form of immunotherapy.

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