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. 2005 Dec;40(12):1390-3.
doi: 10.1016/j.ejmech.2005.08.002. Epub 2005 Oct 13.

Polyamidoamine dendrimers used as solubility enhancers of ketoprofen

Cheng Yiyun  1 , Xu Tongwen, Fu Rongqiang
Affiliations

Polyamidoamine dendrimers used as solubility enhancers of ketoprofen

Cheng Yiyun et al. Eur J Med Chem. 2005 Dec.

Abstract

Ketoprofen is a non-steroidal anti-inflammatory drug which is not freely soluble in water and creates gastrointestinal problems. In the present study we investigated the potential of polyamidoamine (PAMAM) dendrimers to increase the solubility of ketoprofen. The effect of variables, such as pH condition, concentration and generation of dendrimer, has been investigated. The experimental results showed that the solubility of ketoprofen in the dendrimer solutions was proportional to dendrimer concentration. Under suitable conditions PAMAM dendrimers can be highly effective used to enhance the solubility of ketoprofen.

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