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. 2005 Dec;30(12):655-8.
doi: 10.1016/j.tibs.2005.09.007. Epub 2005 Oct 13.

Regulating mammalian transcription with RNA

David R Corey  1
Affiliations

Regulating mammalian transcription with RNA

David R Corey. Trends Biochem Sci. 2005 Dec.

Abstract

Recent reports have demonstrated that small duplex RNAs mediate recognition of chromosomal DNA and inhibit transcription within mammalian cells. Key unresolved issues include whether RNAs directly bind to DNA, the identification of the mechanism(s) that convert chromosome recognition into gene silencing and whether naturally occurring antigene RNAs (agRNAs) exist.

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