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Review
. 2005 Oct;23(4):344-6.
doi: 10.1016/j.immuni.2005.10.001.

Macrophage polarization comes of age

Alberto Mantovani  1 , Antonio Sica, Massimo Locati
Affiliations
Free article
Review

Macrophage polarization comes of age

Alberto Mantovani et al. Immunity. 2005 Oct.
Free article

Abstract

Functional polarization of macrophages into M1 or M2 cells is an operationally useful, simplified conceptual framework describing the plasticity of mononuclear phagocytes. Genetic approaches have begun to shed new light on mechanisms underlying macrophage polarization and on the actual in vivo significance of polarized M2 cells ( [this issue of Immunity]).

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