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. 2005 Oct;140(4):762-4.
doi: 10.1016/j.ajo.2005.04.044.

Test-retest reproducibility of optic disk deterioration detected from stereophotographs by masked graders

Richard K Parrish 2nd  1 , Joyce C Schiffman, William J Feuer, Douglas R Anderson, Donald L Budenz, Maria-Cristina Wells-Albornoz, Ruth Vandenbroucke, Michael A Kass, Mae O Gordon; Ocular Hypertension Treatment Study Group
Affiliations

Test-retest reproducibility of optic disk deterioration detected from stereophotographs by masked graders

Richard K Parrish 2nd et al. Am J Ophthalmol. 2005 Oct.

Abstract

Purpose: To assess the reproducibility of determining whether an eye has developed optic disk deterioration by the Optic Disc Reading Center (ODRC) in the Ocular Hypertension Treatment Study (OHTS).

Design: Test-retest reproducibility study.

Methods: Masked, certified graders at the ODRC determine the occurrence of optic disk deterioration in OHTS by comparing baseline with follow-up stereoscopic optic disk photographs. To assess reproducibility, re-gradings were obtained annually by inserting masked "quality control" photographs into the usual ODRC reading stream.

Results: Agreement (kappa) ranged from 0.65 to 0.83 over 5 years. Specificity ranged from 98% to 100%, and sensitivity ranged from 64% to 81%.

Conclusions: The kappa statistic for test-retest agreement in OHTS is in the range considered good to excellent over 5 years. Consistency (specificity) in re-grading optic disks that did not develop deterioration was particularly high. The sensitivity results show that detecting subtle deterioration of optic disks is challenging.

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