Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2005 Dec;95(6):776-81.
doi: 10.1093/bja/aei257. Epub 2005 Oct 14.

Predictive perioperative factors for developing severe sepsis after major surgery

D Mokart  1 , M Leone, A Sannini, J P Brun, A Tison, J R Delpero, G Houvenaeghel, J L Blache, C Martin
Affiliations
Free article

Predictive perioperative factors for developing severe sepsis after major surgery

D Mokart et al. Br J Anaesth. 2005 Dec.
Free article

Abstract

Background: Early identification of high-risk patients undergoing major surgery can result in an aggressive management affecting the outcome.

Methods: We designed a prospective cohort study of 93 adult patients undergoing major oncological surgery to identify the predictive risk factors for developing postoperative severe sepsis.

Results: Nineteen of 93 patients developed a severe sepsis after surgery; seven of the septic patients died in intensive care unit. Multivariate analysis discriminated preoperative and postoperative (first and second day after surgery) predictive risk factors. The postoperative severe sepsis was independently associated with preoperative factors like male gender (OR 4.7, 95% CI between 1.5 and 15.5, P<0.01) and Charlson co-morbidity index (OR 1.3, 95% CI between 1.07 and 1.6, P<0.01). After the surgery, the presence of systemic inflammatory response syndrome (OR 4.0, 95% CI between 1.02 and 15.7, P<0.05) and a logistic organ dysfunction score on day 2 (OR 3.3, 95% CI between 1.9 and 5.7, P<0.001) were found as independent predictive factors.

Conclusion: We have shown that some of the markers that can be easily collected in the preoperative or postoperative visits can be used to screen the patients at high risk for developing severe sepsis after major surgery.

PubMed Disclaimer