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. 2005 Nov;54(11):1660-1.
doi: 10.1136/gut.2005.077404.

Transcriptional downregulation of the lactase (LCT) gene during childhood

H Rasinperä, M Kuokkanen, K-L Kolho, H Lindahl, N S Enattah, E Savilahti, A Orpana, I Järvelä

Transcriptional downregulation of the lactase (LCT) gene during childhood

H Rasinperä et al. Gut. 2005 Nov.
No abstract available

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Figures

Figure 1
Figure 1
Relation of age to relative expression of lactase LCT mRNA from the C−13910 compared with that from the T−13910 allele. Actual relative expression of the C allele in the biopsy sample was obtained by relating the results of the minisequencing to an 11 point standard curve (y = 0.0135× − 0.9714 up to 82%; y  =  1×10−5e0.1129x for 82–100%) obtained based on information of the relative amounts of G and A in a G/A+593 heterozygous genomic DNA sample (for details of methods, see Kuokkanen et al3).
See this image and copyright information in PMC

References

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    1. Rasinperä H, Savilahti E, Enattah N, et al. Genetic test, which can be used to diagnose adult-type hypolactasia in children. Gut 2004;53:1571–6. - PMC - PubMed
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