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Clinical Trial
. 2005 Nov 4;19(16):1915-6.
doi: 10.1097/01.aids.0000189855.06194.ce.

Evidence of activity of Irinotecan in patients with advanced AIDS-related Kaposi's sarcoma

Emanuela Vaccher  1 , Giampiero di Gennaro, Cecilia Simonelli, Ornella Schioppa, Umberto Tirelli; Italian Cooperative Group on AIDS, Tumors (GICAT)
Affiliations
Clinical Trial

Evidence of activity of Irinotecan in patients with advanced AIDS-related Kaposi's sarcoma

Emanuela Vaccher et al. AIDS. .

Abstract

Fourteen HIV-infected patients with advanced Kaposi's sarcoma (KS) received Irinotecan 150 mg/m intravenously on days 1 and 10. All patients were relapsed/progressed during highly active antiretroviral therapy, administered as primary antineoplastic therapy. An objective response, all partial remissions, occurred in 75% of patients. Irinotecan was well tolerated, severe leukopenia occurred in only 33% of patients. In HIV-infected patients with advanced KS, irinotecan is active and well tolerated.

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