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. 2005 Nov 4;19(16):1916-9.
doi: 10.1097/01.aids.0000189860.36688.e5.

K65R and Y181C are less prevalent in HAART-experienced HIV-1 subtype A patients

Ravindra K Gupta  1 , Ian L Chrystie, Siobhan O'Shea, Jane E Mullen, Ranjababu Kulasegaram, Cheuk Y W Tong
Affiliations

K65R and Y181C are less prevalent in HAART-experienced HIV-1 subtype A patients

Ravindra K Gupta et al. AIDS. .

Abstract

The vast majority of HIV-1 infections globally are caused by subtype A or C, although little is known about their drug resistance profiles. We found that HAART-experienced patients infected with subtype A had a lower prevalence of K65R and Y181C than those with subtypes B or C, despite similar exposure to antiretroviral agents that select for these mutations. If confirmed, this information may be important in the planning of antiretroviral regimens in patients infected with HIV-1 subtype A.

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