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Comparative Study
. 2005 Nov;12(11):1017-8.
doi: 10.1038/nsmb1001.

A minimal domain responsible for Munc13 activity

Jayeeta Basu  1 , Nan Shen, Irina Dulubova, Jun Lu, Rong Guan, Oleg Guryev, Nick V Grishin, Christian Rosenmund, Josep Rizo
Affiliations
Comparative Study

A minimal domain responsible for Munc13 activity

Jayeeta Basu et al. Nat Struct Mol Biol. 2005 Nov.

Abstract

Munc13 proteins are essential in neurotransmitter release, controlling the priming of synaptic vesicles to a release-ready state. The sequences responsible for this priming activity are unknown. Here we identify a large alpha-helical domain of mammalian Munc13-1 that is autonomously folded and is sufficient to rescue the total arrest in neurotransmitter release observed in hippocampal neurons lacking Munc13s.

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