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Case Reports
. 2005 Oct 20;437(7062):1108.
doi: 10.1038/4371108a.

Avian flu: isolation of drug-resistant H5N1 virus

Q Mai Le  1 , Maki Kiso, Kazuhiko Someya, Yuko T Sakai, T Hien Nguyen, Khan H L Nguyen, N Dinh Pham, Ha H Ngyen, Shinya Yamada, Yukiko Muramoto, Taisuke Horimoto, Ayato Takada, Hideo Goto, Takashi Suzuki, Yasuo Suzuki, Yoshihiro Kawaoka
Affiliations
Case Reports

Avian flu: isolation of drug-resistant H5N1 virus

Q Mai Le et al. Nature. .

Erratum in

  • Nature. 2005 Dec 8;438(7069):754

Abstract

The persistence of H5N1 avian influenza viruses in many Asian countries and their ability to cause fatal infections in humans have raised serious concerns about a global flu pandemic. Here we report the isolation of an H5N1 virus from a Vietnamese girl that is resistant to the drug oseltamivir, which is an inhibitor of the viral enzyme neuraminidase and is currently used for protection against and treatment of influenza. Further investigation is necessary to determine the prevalence of oseltamivir-resistant H5N1 viruses among patients treated with this drug.

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