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Case Reports
. 2006 Jan;448(1):85-9.
doi: 10.1007/s00428-005-0094-0. Epub 2005 Oct 14.

Recurrent high-grade leiomyosarcoma with heterologous osteosarcomatous differentiation

Florian Grabellus  1 , Sien-Yi Sheu, Boris Schmidt, Michael Flasshove, Cornelius Kuhnen, Steffen Ruchholtz, Georg Taeger, Kurt Werner Schmid
Affiliations
Case Reports

Recurrent high-grade leiomyosarcoma with heterologous osteosarcomatous differentiation

Florian Grabellus et al. Virchows Arch. 2006 Jan.

Abstract

Leiomyosarcomas (LM) of the soft tissue comprise approximately 5-10% of all soft tissue sarcomas. Besides the classic LM, several distinctly uncommon features of the cellular and growth patterns of LM have been described. The term "dedifferentiated LM" has rarely been used in the literature to describe soft tissue LM containing areas of undifferentiated, pleomorphic appearance or detectable heterologous differentiation. We report on a case of high-grade LM with almost entire transition to an osteosarcoma, which was classified as recurrent high-grade LM with heterologous osteosarcomatous differentiation. The identification of areas with osteosarcomatous dedifferentiation in soft tissue sarcomas can be of clinical importance because of a possible change in oncologic treatment strategies.

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