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. 2005 Sep;11(9):1363-9.
doi: 10.3201/eid1109.041207.

Fluoroquinolone-resistant Escherichia coli, Indonesia

Kuntaman Kuntaman  1 , Endang Sri Lestari, Juliëtte A Severin, Irma M Kershof, Ni Made Mertaniasih, Marijam Purwanta, Usman Hadi, James R Johnson, Alex van Belkum, Henri A Verbrugh; Antimicrobial Resistance in Indonesia, Prevalence and Prevention Study Group
Affiliations

Fluoroquinolone-resistant Escherichia coli, Indonesia

Kuntaman Kuntaman et al. Emerg Infect Dis. 2005 Sep.

Abstract

In a recent, population-based survey of 3,996 persons in Indonesia, fluoroquinolone (FQ)-resistant Escherichia coli was prevalent in the fecal flora of 6% of patients at hospital admission and 23% of patients at discharge, but not among healthy relatives or patients visiting primary healthcare centers (2%). Molecular typing showed extensive genetic diversity with only limited clonality among isolates. This finding suggests that independent selection of resistant mutants occurs frequently. FQ-resistant isolates exhibited a higher rate of spontaneous mutation, but sparser virulence profiles, than FQ-susceptible isolates from the same population. The resistant isolates belonged predominantly to phylogenetic groups A (57%) and B1 (22%) but also to the moderately virulent group D (20%). Hypervirulent strains from the B2 cluster were underrepresented (1%). Because FQ-resistant E. coli can cause disease, especially nosocomial infections in immunocompromised patients, spread of such strains must be stopped.

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Figures

Figure
Figure
Box plot of relative mutation rate of 10 fluoroquinolone (FQ)-resistant (FQREC) and 10 FQ-sensitive (FQSEC) Escherichia coli.
See this image and copyright information in PMC

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