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Case Reports
. 2005 Jun;25(3):205-10.
doi: 10.1016/s0242-6498(05)80111-7.

[Thymic neuroendocrine tumors: report on 6 cases]

[Article in French]
Lara Chalabreysse  1 , Carole Gengler, Sana Sefiani, David Meyronet, Françoise Thivolet-Béjui
Affiliations
Case Reports

[Thymic neuroendocrine tumors: report on 6 cases]

[Article in French]
Lara Chalabreysse et al. Ann Pathol. 2005 Jun.

Abstract

Aim: the aim of our study was to analyze a series of 6 thymic neuroendocrine tumors (TNET).

Methods: we report the clinical and pathological features of 6 TNET reclassified according to the last WHO classification (2004).

Results: there were 4 men and 2 women, (mean age of 61.3 years), presenting with local symptoms in 4 cases. The tumors were reclassified as 3 atypical carcinoids (AC), 2 small cell carcinomas (SCC) and 1 large cell neuroendocrine carcinoma (LCNEC). Cytokeratin, EMA and neuroendocrine markers were expressed in poorly-differentiated tumors. Two patients were lost of follow-up. Two patients with AC died of disease at 20 and 36 months. One patient with SCC died of disease at 2 years and the patient with the LCNEC died of disease in 3 months.

Conclusion: TNET are poor prognosis tumors with a prognosis similar to thymic carcinomas. Adequate surgical resection is a strong prognosis factor.

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