doi: 10.1002/ijc.21518.
Cancer incidence of persons with Down syndrome in Finland: a population-based study
Affiliations
- PMID: 16231334
- DOI: 10.1002/ijc.21518
Item in Clipboard
Cancer incidence of persons with Down syndrome in Finland: a population-based study
Int J Cancer.
.
Abstract
Individuals with Down syndrome (DS) have a predisposition to leukaemia and testicular cancer, but data on the incidence of cancers are yet sparse. A cohort of 3,581 persons with DS was identified from a National Registry of Finnish persons with intellectual disability collected between 1978 and 1986 and followed-up for cancer incidence until 2002. Standardised incidence ratios (SIRs) were defined as ratios of observed number of cancer cases to those expected from the national cancer incidence rates, by age and sex. The overall cancer risk was equal to that of the general population, but a significantly high risk of leukaemia (SIR 10.5, CI 95% 6.6-15.8) and testicular cancer (SIR4.8, CI 95% 1.8-10.4) was found.
Similar articles
-
[Occurrence of cancer in individuals with Down syndrome].Ugeskr Laeger. 2000 Aug 21;162(34):4535-9. Ugeskr Laeger. 2000. PMID: 10981221 Danish.
-
[Incidence of cancer in individuals with Down syndrome].Tidsskr Nor Laegeforen. 2000 Oct 10;120(24):2878-81. Tidsskr Nor Laegeforen. 2000. PMID: 11143409 Danish.
-
Risks of leukaemia and solid tumours in individuals with Down's syndrome.Lancet. 2000 Jan 15;355(9199):165-9. doi: 10.1016/S0140-6736(99)05264-2. Lancet. 2000. PMID: 10675114
-
Pattern of malignant disorders in individuals with Down's syndrome.Lancet Oncol. 2001 Jul;2(7):429-36. doi: 10.1016/S1470-2045(00)00435-6. Lancet Oncol. 2001. PMID: 11905737 Review.
-
Epidemiology of leukemia in children with Down syndrome.Pediatr Blood Cancer. 2005 Jan;44(1):8-12. doi: 10.1002/pbc.20165. Pediatr Blood Cancer. 2005. PMID: 15390275 Review.
Cited by
-
Rac1-mediated cytoskeleton rearrangements induced by intersectin-1s deficiency promotes lung cancer cell proliferation, migration and metastasis.Mol Cancer. 2016 Sep 14;15(1):59. doi: 10.1186/s12943-016-0543-1. Mol Cancer. 2016. PMID: 27629044 Free PMC article.
-
Selecting variants of unknown significance through network-based gene-association significantly improves risk prediction for disease-control cohorts.Sci Rep. 2019 Mar 1;9(1):3266. doi: 10.1038/s41598-019-39796-w. Sci Rep. 2019. PMID: 30824863 Free PMC article.
-
Clinical and biological aspects of myeloid leukemia in Down syndrome.Leukemia. 2021 Dec;35(12):3352-3360. doi: 10.1038/s41375-021-01414-y. Epub 2021 Sep 13. Leukemia. 2021. PMID: 34518645 Free PMC article. Review.
-
Potential Role of JAK-STAT Signaling Pathway in the Neurogenic-to-Gliogenic Shift in Down Syndrome Brain.Neural Plast. 2016;2016:7434191. doi: 10.1155/2016/7434191. Epub 2016 Jan 12. Neural Plast. 2016. PMID: 26881131 Free PMC article. Review.
-
Down syndrome with cryptorchidism and retroperitoneal mixed germ cell tumour in an adult patient: a case report and literature review.World J Surg Oncol. 2025 Jan 24;23(1):19. doi: 10.1186/s12957-024-03589-x. World J Surg Oncol. 2025. PMID: 39856688 Free PMC article. Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical
