doi: 10.1021/ja054010h.
A highly efficient carbon-carbon bond formation reaction via nucleophilic addition to N-alkylaldimines without acids or metallic species
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- PMID: 16231887
- DOI: 10.1021/ja054010h
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A highly efficient carbon-carbon bond formation reaction via nucleophilic addition to N-alkylaldimines without acids or metallic species
J Am Chem Soc.
.
Abstract
A nucleophilic addition reaction to N-methylaldimines without acid or metal species is described. A novel reagent, dicyanomethyl acetate, is used as a nucleophile to give alpha-(N-methyl-N-acetyl)amino acid methyl esters in excellent yield.
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