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Comment
. 2005 Oct;2(10):e342.
doi: 10.1371/journal.pmed.0020342. Epub 2005 Oct 25.

Pharmacogenetics in the management of coumarin anticoagulant therapy: the way forward or an expensive diversion?

Mike Greaves  1
Affiliations
Comment

Pharmacogenetics in the management of coumarin anticoagulant therapy: the way forward or an expensive diversion?

Mike Greaves. PLoS Med. 2005 Oct.

Abstract

Greaves discusses a new study in PLoS Medicine that takes us closer to being able to adopt a pharmacogenetic approach to reduce bleeding risk from coumarin therapy.

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Conflict of interest statement

Competing Interests: I have been a paid expert advisor, on an ad hoc basis, to AstraZeneca (London, United Kingdom), a company developing thrombin inhibitors. I have no financial interest in this company's success (I have no shares in the company, nor have I received grants or awards from the company).

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References

    1. Li T, Chang CY, Jin DY, Lin PJ, Khvorova A, et al. Identification of the gene for vitamin K epoxide reductase. Nature. 2004;427:541–544. - PubMed
    1. Palareti G, Leali N, Coccheri S, Poggi M, Manotti C, et al. Bleeding complications of oral anticoagulant treatment: An inception-cohort, prospective collaborative study (ISCOAT). Italian Study on Complications of Oral Anticoagulant Therapy. Lancet. 1996;348:423–428. - PubMed
    1. Panneerselvam S, Baglin C, Lefort W, Baglin T. Analysis of risk factors for over-anticoagulation in patients receiving long-term warfarin. Brit J Haematol. 1998;103:422–424. - PubMed
    1. Lubetsky A, Dekel-Stem E, Chetrit A, Lubin F, Halkin H. Vitamin K intake and sensitivity to warfarin in patients consuming regular diets. Thrombos Haemostas. 1999;81:396–399. - PubMed
    1. Yu HC, Chan TY, Critchley JA, Woo KS. Factors determining the maintenance dose of warfarin in Chinese patients. QJM. 1996;89:127–135. - PubMed