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Review
. 2005 Nov;33(5):425-31.
doi: 10.1165/rcmb.F307.

One hundred years of research in the pathogenesis of pulmonary hypertension

Ari Zaiman  1 , Iwona Fijalkowska, Paul M Hassoun, Rubin M Tuder
Affiliations
Review

One hundred years of research in the pathogenesis of pulmonary hypertension

Ari Zaiman et al. Am J Respir Cell Mol Biol. 2005 Nov.
No abstract available

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Figures

<b>Figure 1.</b>
Figure 1.
Timeline of significant achievements in the last 100 years of pulmonary hypertension research.
<b>Figure 2.</b>
Figure 2.
Pulmonary vascular remodeling in a lung of a patient with IPAH. (a) Pulmonary artery with medial hypertrophy (arrowhead), with intima thickening by longitudinally oriented smooth muscle cells (arrow). (b) Pulmonary artery with marked medial and intima thickening, with crenated internal elastic layer (dark arrow), suggestive of vasoconstriction. (c) Peripheral muscularization of a small precapillary pulmonary artery (arrowhead), also showing intima thickening. (d) Peripheral pulmonary artery with collagenous intima thickening (arrow). (e) Plexiform lesion (arrow) surrounded by markedly vascular dilation compromising both vessels draining the lesion and in alveolar capillaries (arrowheads). (f) Longitudinal section of a pulmonary artery with a concentric arrangement of elongated smooth muscle cell–like cells (arrow) and a plexiform lesion (flanked by arrowheads). (g) Concentric lesion cross-sectioned (arrow). (h) Plexiform lesion (arrowheads) and an adjoining pulmonary artery with marked intima thickening leading to reduction of vascular lumen (bar = 20 μm in a–d and g; 200 μm in e, f, and h).
See this image and copyright information in PMC

References

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