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. 2005 Oct 27;7(22):4795-8.
doi: 10.1021/ol050848y.

Synthesis of biologically active amines via rhodium-bisphosphite-catalyzed hydroaminomethylation

John R Briggs  1 , Jerzy Klosin, Gregory T Whiteker
Affiliations

Synthesis of biologically active amines via rhodium-bisphosphite-catalyzed hydroaminomethylation

John R Briggs et al. Org Lett. .

Abstract

[reaction: see text] We report the use of a highly regioselective rhodium-bisphosphite catalyst for olefin hydroaminomethylation. This catalyst system was successfully applied in the synthesis of two biologically active tertiary amines, ibutilide and aripiprazole.

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