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. 2005 Oct 27;7(22):4871-4.
doi: 10.1021/ol051615+.

Efficient cross-coupling of functionalized arylzinc halides catalyzed by a nickel chloride-diethyl phosphite system

Andrei Gavryushin  1 , Christiane Kofink, Georg Manolikakes, Paul Knochel
Affiliations

Efficient cross-coupling of functionalized arylzinc halides catalyzed by a nickel chloride-diethyl phosphite system

Andrei Gavryushin et al. Org Lett. .

Abstract

[reaction: see text] The combination of diethyl phosphite and DMAP as ligands for nickel in an 8:1 THF-N-ethylpyrrolidinone (NEP) mixture allows a very efficient cross-coupling reaction to be performed between various functionalized arylzinc halides and aryl bromides, triflates and activated chlorides. The reaction proceeds at 25 degrees C within 1-48 h and requires only 0.05 mol % of the nickel catalyst.

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