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. 2006 Jan 1;16(1):123-8.
doi: 10.1016/j.bmcl.2005.09.037. Epub 2005 Oct 19.

Discovery, SAR, and X-ray structure of novel biaryl-based dipeptidyl peptidase IV inhibitors

Lei Qiao  1 , Christian A Baumann, Carl S Crysler, Nisha S Ninan, Marta C Abad, John C Spurlino, Renee L Desjarlais, Jukka Kervinen, Mike P Neeper, Shariff S Bayoumy, Robyn Williams, Ingrid C Deckman, Malini Dasgupta, Rolanda L Reed, Norman D Huebert, Bruce E Tomczuk, Kevin J Moriarty
Affiliations

Discovery, SAR, and X-ray structure of novel biaryl-based dipeptidyl peptidase IV inhibitors

Lei Qiao et al. Bioorg Med Chem Lett. .

Abstract

The discovery, SAR, and X-ray crystal structure of novel biarylaminoacyl-(S)-2-cyano-pyrrolidines and biarylaminoacylthiazolidines as potent inhibitors of dipeptidyl peptidase IV (DPP IV) are reported.

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