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Comment
. 2005 Oct 21;123(2):185-7.
doi: 10.1016/j.cell.2005.10.004.

ADAM and Eph: how Ephrin-signaling cells become detached

Filippo Mancia  1 , Lawrence Shapiro
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Comment

ADAM and Eph: how Ephrin-signaling cells become detached

Filippo Mancia et al. Cell. .
Free article

Abstract

Ephrin ligands presented on one cell surface associate with their receptors on the surface of a juxtaposed cell, often resulting in cell-cell repulsion. In this issue of Cell, Janes et al. (2005) show that the ephrin ligand can be proteolytically released from its membrane tether by a complex on the opposing cell composed of the ephrin receptor and an ADAM metalloprotease.

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