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. 1992;42(6):689-91.
doi: 10.1007/BF00265939.

Pharmacokinetics of diphemanil methylsulphate in healthy subjects

A M Vidal  1 , E Rey, G Pons, J Y Pello, P d'Athis, G Olive
Affiliations

Pharmacokinetics of diphemanil methylsulphate in healthy subjects

A M Vidal et al. Eur J Clin Pharmacol. 1992.

Abstract

The pharmacokinetic parameters of oral diphemanil methylsulphate have been evaluated in six healthy male volunteers. Absorption of the drug was slow (tmax = 2 to 4 h), the mean half-life was 8.35 h, and the amount of the drug recovered in urine within 48 h ranged from 0.6 to 7.4% of the administered dose. The results suggest low bioavailability, assuming that the drug is poorly metabolized.

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