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. 2005 Nov;53(5):890-2.
doi: 10.1016/j.jaad.2005.07.030.

Frequent varicella zoster reactivation associated with therapeutic use of arsenic trioxide: portents of an old scourge

Wing-Yan Au  1 , Yok-Lam Kwong
Affiliations

Frequent varicella zoster reactivation associated with therapeutic use of arsenic trioxide: portents of an old scourge

Wing-Yan Au et al. J Am Acad Dermatol. 2005 Nov.

Abstract

In 44 patients treated with arsenic trioxide (As2(O3)) for acute promyelocytic leukemia, 11 developed varicella zoster virus (VZV) reactivation (median 56 days [range 15-299]) after treatment. There was no preferential dermatome involvement or systemic spread. The actuarial risk of VZV reactivation at 1 year was 26%. No VZV reactivation occurred after the first year of initial treatment with As2(O3).

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