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Comparative Study
. 1992 May;45(5):679-85.
doi: 10.7164/antibiotics.45.679.

L-696,474, a novel cytochalasin as an inhibitor of HIV-1 protease. II. Isolation and structure

J Ondeyka  1 , O D Hensens, D Zink, R Ball, R B Lingham, G Bills, A Dombrowski, M Goetz
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Free article
Comparative Study

L-696,474, a novel cytochalasin as an inhibitor of HIV-1 protease. II. Isolation and structure

J Ondeyka et al. J Antibiot (Tokyo). 1992 May.
Free article

Abstract

A novel HIV-1 protease inhibitor, L-696,474 (C30H39NO4, 477), was isolated from the fermentations of the fungus Hypoxylon fragiforme (ATCC 20995, MF5511) and purified by silica gel chromatography followed by crystallization. Spectroscopic studies have shown the competitive inhibitor L-696,474 to be a novel cytochalasin. Two related novel cytochalasins were also isolated and had no effect on the enzyme.

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