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. 2005 Nov;112(11):1479-85.
doi: 10.1007/s00702-005-0391-4.

Amygdala responsiveness is modulated by tryptophan hydroxylase-2 gene variation

T Canli  1 , E Congdon, L Gutknecht, R T Constable, K P Lesch
Affiliations

Amygdala responsiveness is modulated by tryptophan hydroxylase-2 gene variation

T Canli et al. J Neural Transm (Vienna). 2005 Nov.

Abstract

The tryptophan hydroxylase-2 gene (TPH2) codes for the enzyme of serotonin (5-HT) synthesis in the brain and variation of TPH2 has been implicated in disorders of emotion regulation. Here, we used functional magnetic resonance imaging (fMRI) to demonstrate that a potentially functional variant of TPH2 modulates amygdala responsiveness to emotional stimuli of both negative and positive valence.

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References

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