Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2005 Apr;189(4):625-33.

[Liver repopulation strategies]

[Article in French]
Hélène Gilgenkrantz  1 , Jacques-Emmanuel Guidotti, Claudia Mitchell, Vincent Olivier Mallet, Axel Kahn
Affiliations
  • PMID: 16245681
Review

[Liver repopulation strategies]

[Article in French]
Hélène Gilgenkrantz et al. Bull Acad Natl Med. 2005 Apr.

Abstract

Hepatocytes have the unique capacity to self-renew and repair the liver ad integrum when stimulated to proliferate by liver injury. However, transplantation of isolated hepatocytes is usually not sufficiently efficient for therapeutic purposes. We conferred a survival advantage on transplanted hepatocytes and showed that they were able to repopulate almost the entire mouse liver after repeated injury. In contrast, we found that bone marrow stem cell transdifferentiation was inadequate for therapeutic liver regeneration. Current data on liver stem cells will be discussed.

PubMed Disclaimer