Critical role of acylglycerol kinase in epidermal growth factor-induced mitogenesis of prostate cancer cells
- PMID: 16246119
- DOI: 10.1042/BST0331362
Critical role of acylglycerol kinase in epidermal growth factor-induced mitogenesis of prostate cancer cells
Abstract
The bioactive phospholipids, LPA (lysophosphatidic acid) and PA (phosphatidic acid), regulate pivotal processes related to the pathogenesis of cancer. Recently, we cloned a novel type of lipid kinase that phosphorylates monoacylglycerols (such as 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand) and diacylglycerols, to form LPA and PA, respectively. This AGK (acylglycerol kinase) is highly expressed in prostate cancer cell lines and the results reviewed here suggest that AGK might be a critical player in the initiation and progression of prostate cancer. Intriguingly, down-regulation of endogenous AGK inhibited EGF (epidermal growth factor), but not LPA-induced ERK1/2 (extracellular-signal-regulated kinase 1/2) activation and progression through the S-phase of the cell cycle. In this review, we will summarize the evidence demonstrating that AGK amplifies EGF growth signalling pathways that play an important role in the pathophysiology of prostate cancer. Because LPA has long been implicated as an autocrine and paracrine growth stimulatory factor for prostate cancer cells, the identification of this novel lipid kinase that regulates its production could provide new and useful targets for preventive or therapeutic measures.
Similar articles
-
Expression of autotaxin and acylglycerol kinase in prostate cancer: association with cancer development and progression.Cancer Sci. 2009 Sep;100(9):1631-8. doi: 10.1111/j.1349-7006.2009.01234.x. Epub 2009 May 31. Cancer Sci. 2009. PMID: 19549252 Free PMC article.
-
Role of acylglycerol kinase in LPA-induced IL-8 secretion and transactivation of epidermal growth factor-receptor in human bronchial epithelial cells.Am J Physiol Lung Cell Mol Physiol. 2009 Mar;296(3):L328-36. doi: 10.1152/ajplung.90431.2008. Epub 2008 Dec 26. Am J Physiol Lung Cell Mol Physiol. 2009. PMID: 19112101 Free PMC article.
-
A novel acylglycerol kinase that produces lysophosphatidic acid modulates cross talk with EGFR in prostate cancer cells.J Cell Biol. 2005 Jun 6;169(5):801-11. doi: 10.1083/jcb.200407123. J Cell Biol. 2005. PMID: 15939762 Free PMC article.
-
Lysophosphatidic acid in airway function and disease.Biochim Biophys Acta. 2002 May 23;1582(1-3):240-50. doi: 10.1016/s1388-1981(02)00177-4. Biochim Biophys Acta. 2002. PMID: 12069834 Review.
-
Lysophosphatidic acid as a lipid mediator with multiple biological actions.J Biochem. 2015 Feb;157(2):81-9. doi: 10.1093/jb/mvu077. Epub 2014 Dec 11. J Biochem. 2015. PMID: 25500504 Review.
Cited by
-
Lysophosphatidic acid signaling in airway epithelium: role in airway inflammation and remodeling.Cell Signal. 2009 Mar;21(3):367-77. doi: 10.1016/j.cellsig.2008.10.010. Epub 2008 Oct 26. Cell Signal. 2009. PMID: 18996473 Free PMC article. Review.
-
The prognostic activity of acylglycerol kinase immunohistochemical expression in colon adenocarcinoma patients.Prz Gastroenterol. 2023;18(4):430-436. doi: 10.5114/pg.2023.133477. Epub 2023 Dec 8. Prz Gastroenterol. 2023. PMID: 38572459 Free PMC article.
-
Acylglycerol kinase inhibits macrophage anti-tumor activity via limiting mtDNA release and cGAS-STING-type I IFN response.Theranostics. 2025 Jan 1;15(4):1304-1319. doi: 10.7150/thno.101298. eCollection 2025. Theranostics. 2025. PMID: 39816692 Free PMC article.
-
Expression of autotaxin and acylglycerol kinase in prostate cancer: association with cancer development and progression.Cancer Sci. 2009 Sep;100(9):1631-8. doi: 10.1111/j.1349-7006.2009.01234.x. Epub 2009 May 31. Cancer Sci. 2009. PMID: 19549252 Free PMC article.
-
Role of acylglycerol kinase in LPA-induced IL-8 secretion and transactivation of epidermal growth factor-receptor in human bronchial epithelial cells.Am J Physiol Lung Cell Mol Physiol. 2009 Mar;296(3):L328-36. doi: 10.1152/ajplung.90431.2008. Epub 2008 Dec 26. Am J Physiol Lung Cell Mol Physiol. 2009. PMID: 19112101 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous