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. 2005;24(5-7):1127-30.
doi: 10.1081/ncn-200060154.

Efficient chemo-enzymatic syntheses of pharmaceutically useful unnatural 2'-deoxynucleosides

Hironori Komatsu  1 , Tadashi Araki
Affiliations

Efficient chemo-enzymatic syntheses of pharmaceutically useful unnatural 2'-deoxynucleosides

Hironori Komatsu et al. Nucleosides Nucleotides Nucleic Acids. 2005.

Abstract

Our chemo-enzymatic method was successfully applied to the synthesis of 2-chloro-2'-deoxyadenosine (CdA, cladribine) in two ways: 1) direct conversion of chemically synthesized 2-deoxy-alpha-D-ribose 1-phosphate (dRP) to CdA; 2) a two-step route via 9-(2-deoxy-beta-D-ribos-1-yl)-2, 6-dichloropurine (Cl2Pu-dR, 5).

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