Review
doi: 10.5483/bmbrep.2002.35.1.061.
Modulation of life and death by the tumor necrosis factor receptor-associated factors (TRAFs)
Affiliations
- PMID: 16248971
- DOI: 10.5483/bmbrep.2002.35.1.061
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Review
Modulation of life and death by the tumor necrosis factor receptor-associated factors (TRAFs)
J Biochem Mol Biol.
.
Abstract
The TNF receptor-associated factor (TRAF) family is a group of adapter proteins that link a wide variety of cell surface receptors. Including the TNF and IL-1 receptor superfamily to diverse signaling cascades, which lead to the activation of NF-kappaB and mitogen-activated protein kinases. In addition, TRAFs interact with a variety of proteins that regulate receptor-induced cell death or survival. Thus, TRAF-mediated signals may directly induce cell survival or interfere with the death receptor-induced apoptosis.
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