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Review
. 2005 Oct;5(10):953-60.
doi: 10.2174/138955705774329500.

Corticotropin-releasing factor binding protein--a ligand trap?

Olaf Jahn  1 , Jelena Radulovic, Oliver Stiedl, Hossein Tezval, Klaus Eckart, Joachim Spiess
Affiliations
Review

Corticotropin-releasing factor binding protein--a ligand trap?

Olaf Jahn et al. Mini Rev Med Chem. 2005 Oct.

Abstract

The actions of the neuropeptide corticotropin-releasing factor (CRF) are modulated by a CRF binding protein (CRFBP). In view of the memory-enhancing effects of CRF, the release of endogenous CRF from CRFBP by CRFBP inhibitors has been suggested as a therapeutical strategy for the treatment of cognitive deficits. This mini-review will summarize recent advances in the field with a focus on the pharmaceutical potential of CRFBP inhibitors.

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