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. 2005 Nov;49(11):4757-9.
doi: 10.1128/AAC.49.11.4757-4759.2005.

Activities of flucytosine, fluconazole, amphotericin B, and micafungin in a murine model of disseminated infection by Candida glabrata

Marçal Mariné  1 , Carolina Serena, Belkys Fernández-Torres, F Javier Pastor, Josep Guarro
Affiliations

Activities of flucytosine, fluconazole, amphotericin B, and micafungin in a murine model of disseminated infection by Candida glabrata

Marçal Mariné et al. Antimicrob Agents Chemother. 2005 Nov.

Abstract

We compared the efficacies of amphotericin B, fluconazole, flucytosine, and micafungin in a systemic murine infection by three isolates of Candida glabrata. Amphotericin B showed the best results, although none of the drugs dramatically reduced mortality or tissue burden in liver or spleen.

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Figures

FIG. 1.
FIG. 1.
Survival of mice after inoculation with C. glabrata. Mice were inoculated intravenously with either 2 × 107 (FMR 8489, □), 2 × 108 (FMR 8489, ▪; FMR 8497, ▾; FMR 8766, ⋄), or 6 × 108 (FMR 8766, ⧫) CFU/animal.
FIG. 2.
FIG. 2.
Cumulative mortality of mice infected with C. glabrata FMR 8497 (A), FMR 8489 (B), and FMR 8766 (C). a, P value of <0.05 versus control.
FIG. 3.
FIG. 3.
Effects of the antifungal treatments on colony counts of the C. glabrata strains FMR 8497 (A) and FMR 8489 (B) in spleens and kidneys of mice. a, P value of <0.05 versus control. Horizontal lines indicate mean values.
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References

    1. Atkinson, B. A., C. Bouthet, R. Bocanegra, A. Correa, M. F. Luther, and J. R. Graybill. 1995. Comparison of fluconazole, amphotericin B and flucytosine in treatment of a murine model of disseminated infection with Candida glabrata in immunocompromised mice. J. Antimicrob. Chemother. 35:631-640. - PubMed
    1. Cuenca-Estrella, M., D. Rodríguez, B. Almirante, J. Morgan, A. M. Planes, M. Almela, J. Mensa, F. Sanchez, J. Ayats, M. Gimenez, M. Salvado, D. W. Warnock, A. Pahissa, and J. L. Rodriguez-Tudela on behalf of the Barcelona Candidemia Project Study Group. 2005. In vitro susceptibilities of bloodstream isolates of Candida species to six antifungal agents: results from a population-based active surveillance programme, Barcelona, Spain, 2002-2003. J. Antimicrob. Chemother. 55:194-199. - PubMed
    1. Diekema, D. J., S. A. Messer, A. B. Brueggemann, S. L. Coffman, G. V. Doern, L. A. Herwaldt, and M. A. Pfaller. 2002. Epidemiology of candidemia: 3-year results from the emerging infections and the epidemiology of Iowa organisms study. J. Clin. Microbiol. 40:1298-1302. - PMC - PubMed
    1. Fisher, M. A., S.-H. Shen, J. Haddad, and W. F. Tarry. 1989. Comparison of in vivo activity of fluconazole with that of amphotericin B against Candida tropicalis, Candida glabrata, and Candida krusei. Antimicrob. Agents Chemother. 33:1443-1446. - PMC - PubMed
    1. Ju, J. Y., C. Polhamus, K. A. Marr, S. M. Holland, and J. E. Bennett. 2002. Efficacies of fluconazole, caspofungin, and amphotericin B in Candida glabrata-infected p47phox−/− knockout mice. Antimicrob. Agents Chemother. 46:1240-1245. - PMC - PubMed

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